One Tree Hill – The on-screen couple fell in love and got married in real life. However, the pair filed for divorce shortly after marriage due to Chad’s alleged affair with Paris Hilton on the sets of the movie House of Wax.
X Files – David Duchovny while speaking to a magazine said that “familiarity breeds contempt….we used to argue about everything and couldn’t stand the sight of each other when the cameras weren’t rolling.”
Blade Runner – The pair from the 1982 sci-fi movie Blade Runner did not get along very well. The tension between them is what led the love scene between them to be nicknamed as the “hate scene” by the cast and crew.
Seinfeld – The on-screen pair starred in the hit TV series Seinfeld. If rumors are to be believed, Heidi was too difficult to work with and this possibly led to her character being written off the show.
The Big Bang Theory – The leading duo of the nerdy TV series The Big Bang Theory couldn’t stand each other post their breakup. It was believed that Johnny found Kaley’s behavior to be egoistic on the sets of the TV series.
I Love Trouble – The significant age gap between the I Love Trouble duo was considered to be the cause of tension. It went to the extent that Julia was recorded calling Nick “disgusting” in an interview.
The Vampire Diaries – The hit pair from the fantasy show The Vampire Diaries found it difficult and awkward with each other. This was because the two dated each other for three years during the show’s run.
Castle – The feud between lead actors of the successful TV series got so real that they had to go to couple’s counseling. Katic left the show after eight seasons, which is seen as an underlying reason of the show’s eventual cancellation.
The Fresh Prince of Bel-Air – Though not a romantic on-screen couple, the costars couldn’t get along on the sets of the sitcom. Hubert alleged that Smith did not help her and other co-stars with salary negotiations. She eventually quit the show.